Prenatal stress impairs recognition memory and leads to neurodevelopmental deficits in hippocampus of adolescent rats with early acute pentylenetetrazole-kindling

Objectives: This study aimed to investigate the effects of prenatal stress (PS) on hippocampus early acute pentylenetetrazole (PTZ)-kindled offspring in adolescence. Recognition memory, morphological changes and synaptophysin levels were evaluated. Methods: Restraint was induced a group pregnant dams non-stressed (NA) remained undisturbed. Next, male female divided as 1. PS-PTZ, 2. PS -control, 3. NA-PTZ 4. NA-control (n = 12 each group). The object recognition test performed following PTZ injection (45 mg/kg) postnatal day 10 (P10). Brains collected 35 (P35) determine neuronal density expression by immuno/-histological studies. Further, oxidative products analyzed with different biochemical assays. Results: impaired memory significantly (p 0.03); however, impairment reversible control compared 0.04). Furthermore, caused loss CA1 0.01) decreased CA3 area 0.03). also increased markers < 0.05). Conclusions: These results suggest that causes neurodevelopmental deficits adolescent after early-life seizures prominently. However, damage only adolescence can be reversible. Therefore, adult other regions brain need further studied.